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Vibrating  Microtome

 

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MODEL HA752

with manual tissue transport

MODEL MA752

with motorized tissue transport

MODEL ROMA752

with motorized tissue transport & remote operation.

 

7550/1SS  Pkg 50 Stainless S. Blades     

7550/1C  Pkg 5 Ceramic Blades

752/1SS  Pkg 50 Stainless S. Blades (for old units only, before 2000)   

 

VIBROSLICE 

 

The instrument has been designed to cut 50 to 700 micron sections of fresh, unfixed tissue for in vitro recordings, tissue culture and microassay work. It can also be used to section fixed tissue down to 20 microns without previous embedding or freezing. The Vibroslice has also been redesigned and considerably upgraded in its performance from the original specification and will section tissue such as brain stem, and liver maintaining the integrity of surface cells for recording. A vibrating blade slices tissues without the traumatic damage of other methods. The blade oscillates at a fixed lateral displacement of 1.0mm at a frequency set by the user and then actuated by a footswitch. If damage should occur to the blade this lateral displacement minimizes scoring of the tissue.

Both frequency of the blade oscillation and the rate of advance of the section are important in producing good quality sections. The Vibroslice is designed to be flexible in its operation and has a removable tissue holder and bath, which allows tissue to be prepared and stored ready for later use, provides easy cleaning and prevents carryover of fixative between fixed and unfixed tissue. Recent product redesign has incorporated a variable angle blade holder for the first time.

The advance speed on the motorized models is now ultra-low being half of the previous model and the speed of oscillation has been raised again. Changing of drive belts is now much easier with the readily removable molded cover.  

 

 

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INTEGRASLICE 

 

Integraslice is designed to produce the very highest quality of slices in the most difficult tissue slicing application. Robust in design and built from the highest specification components, both models accommodate the following optional equipment: -

·         Campden Instruments precision blade technology in stainless steel or zirconium ceramic.

·         Tissue baths and cutting heads that can be removed for autoclaving or simply cleaning.

·         Optional, integrally fitted Inspection Microscope and / or Cold Light Source.

·         Optional Tissue Bath with Temperature Controller to cool or warm to +/- 0.5o C.

 

MODEL 7550PSDS

for fully Programmable cutting profiles of Speed, Distance and Section thickness.

Features include Dynamically Adjustable Speed and Amplitude [DASA]

MODEL 7550MM

for Motorised or Manual advance of the oscillating blade

 

7550/1SS  Pkg 50 Stainless S. Blades      

7550/1C  Pkg 5 Ceramic Blades

 

 

 

 

The McIlwain Tissue Chopper has been designed to prepare samples of tissue for metabolic experiments and is particularly suitable for small and irregular samples for biopsy or from small organs. For Neuroscience it offers the opportunity for rapid chopping of tissue such as hippocampus, which is relatively, flat and will not suffer excessive stress damage. For slicing cortical or sub-cortical regions Campden’s "Vibroslice" will provide precise and gentle slice sectioning. The tissue chopper is also good for preparing cell cultures from the brain of young animals.

Its operation is such that it will cause much less disturbance of cell structure than would a blender or homogeniser, and it can be used on fragments which would be difficult to cut by ordinary methods. Typical applications are for liver, kidney and parts of the central nervous system. Preparation of 1mm thick slices or cubes and prism samples can be prepared in 30 seconds. The Chopper offers stepless variation of slice thickness from zero to maximum by means of an indexing clutch in conjunction with micrometer head calibrated in microns. Code  TC752

 

McILWAIN TISSUE CHOPPER

 

 

TISSUE BATH COOLER   

The 7600 enables the cooling of physiological fluid and tissue from normal room temperature to freezing point in approximately 5 to 6 minutes. The 7600 Cooler will achieve zero in about 4 minutes and has the capacity to go as low as minus 2 celcius.

The result of slicing at correct temperature is twofold.

Firstly the slice quality is improved and secondly the unfixed tissue is preserved for in vitro recording. Fresh tissue needs to be cooled as rapidly as possible to reduce its oxygen demand whilst perfusing, typically with 5% oxygen. The cooled bath fits onto the Vibroslice exactly as the standard bath and takes its power from the nearby control unit.

 

Cooler for Vibroslice/Integraslice  model 7600

 

Tissue Slicer  

 

Originally designed to prepare thin slices of living brain, the tissue slicer is also excellent for slicing other tissues, in the blocking of fixed tissue for histology, and in the slicing of electrophoretic gels. Sections as thin as 150 microns can be reliably prepared.

The 51425 Tissue Slicer has a conventional vernier micrometer, with a resolution of 10 microns.

The 51415 Digital Tissue Slicer has a digital display electronic micrometer, with 1 micron resolution. Switch from mm to inches, set zero at any point, set low and high tolerance limits. Features an over-travel warning signal and output to a printer, processor, data logger or computer.

Code 51425 Manual Tissue Slicer

Code 51415 Digital Tissue Slicer

 

 

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RODENT BRAIN MATRIX-RBM

 

We offer one of the largest selections of brain matrices available. Made of acrylic, or stainless steel, these matrices are sturdy and can be heated, chilled, autoclaved (stainless steel only), scrubbed and stand up to rigorous daily use. Coronal matrices have the additional feature of a mid-line sagittal cut to facilitate splitting of the left and right hemispheres. Sections can be as fine as 1 mm. The olfactory/spinal/notch is cut into each matrix.

 

Code: BLADES : Pkg of 100 blades for Brain Matrix

RBMA-200C    Adult Mouse Coronal - Plastic   

RBMA-200S    Adutl Mouse Sagittal -  Plastic

RBMA-300C    Rat 175-300 g Coronal   - Plastic

RBMA-300S    Rat 175-300 g  Sagittal  -  Plastic

 

RBMA-600C    Rat 300-600 g  Coronal  -  Plastic

RBMA-600S    Rat 300-600 g  Sagittal  -  Plastic

RBMS-200C    Adult Mouse Coronal – Stainless Steel   

RBMS-200S    Adutl Mouse Sagittal -  Stainless Steel   

RBMS-300C    Rat 175-300 g Coronal   - Stainless Steel   

RBMS-300S    Rat 175-300 g  Sagittal  -  Stainless Steel   

RBMS-600C    Rat 300-600 g  Coronal  -  Stainless Steel   

RBMS-600S    Rat 300-600 g  Sagittal  -  Stainless Steel   

 

 

Slice Workstation' Multichannel Observation Systems

Code 746 is a  Slice Workstation intended for the simultaneous evaluation or observation of either 4 or 8 slices in submerged or interface type chambers. Details of the slice chambers are available on request.
The unit comprises a support frame upon which is mounted an anti-vibration table and camera assembly. The slice chamber is mounted on the anti-vibration table under the camera assembly (two camera assemblies for the 8-slice version). The camera assembly houses 4 ccd colour cameras each of which is individually adjustable for focus. The camera assembly can be swung upwards away from the chamber for easy access to the chamber. In its raised position the camera assembly is supported by a gas spring strut. In its lowered position it is held in place by a spring latch. The cameras are connected to a suitable power supply and quad processor. Output from the quad processor is to a video monitor and/or video recorder or computer.

 

 

 

 

 

Slice Chambers for Blind Patching & Extracellular Recording 

Model 745 Series (E)

Compact and modular; easy to set up, easy to swap between submerged and interface modes. Consistently stable fluid flow and stable temperature.  

The Chambers

Manufactured from Plexiglas, or, for pharmacological or toxicological studies chemically inert p.t.f.e. (Teflon®) to avoid adhesion of drugs.

Ag/AgCl reference electrodes included with termination points, easily replaceable

The one, two or four channel chambers can be used either in the classical submerged [Oslo type] or in the air/fluid interface [Haas Type] with humidified atmosphere above the tissue slices.

To convert from submerged to interface type, simply exchange the chamber top plate

Heated water bath has a low noise heating element and gas tube to prevent oxygen loss from perfusate solution.  Holding chamber for incubation of slices until transfer to recording chamber.  Stable Temperature control by dual thermistor feedback from water bath and slice chamber. Ergonomic design for access from either side with  micromanipulators

Applications:

Brain - Action Potentials from Hippocampal Slice

Heart - Double Pulse Stimulation to evaluate refractory period of cardiac action potential recorded from ventricular part of the cardiac tissue slice.

 

 

Visual Patching and Imaging Chamber       Model 7800 Series

The Chamber

Just put it on the microscope stage, plug in the controller, connect the tubing and switch it on. Objective lens heater plugs into controller to provide unobtrusive control of the environment above the chamber. Low profile for easy access of electrodes under the heated objective lens when mounted on upright microscopes. No electromagnetic noise emission from the DC power source. Annular ring adapter to fit all types of upright and inverted microscopes. Adapts to 22mm coverslip or 35mm petri dish. Laminar flow of fluids across the centre of the chamber. Chambers are coated  with chemically inert p.t.f.e. (Teflon®) to avoid adhesion of drugs. Gas inlet through heat exchanger into chamber for hypoxia studies, hydrophobic p.t.f.e. resists flooding into gas inlets. Unique design of suction capillary ensures a steady state of flow and a mill pond smooth surface in a shallow pool of 1mm depth. Ag/AgCl reference wire is simply placed within the chamber. Vented lid seals the chamber for hypoxia studies.

 

Applications:

- Electrophysiology

- Imaging

- Including studies with hypoxia

 

 

 

Digital Calipers  

 

Electronic digital calipers are a joy to work with.  Readings in inches or metric at the touch of a button.

Resolution of .001” or 0.01 mm.

Floating zero feature allows scale to read plus or minus a set point without calculations. Stainless steel. Lockable.

 

Code  58750  Digital Caliper

 

 

Non-rotating Spindle Digital Micrometer Head

Build your own precision micro-positioning device.

The new non-rotating spindle digital micrometer head allows you to create your own micro-positioning instrument. With micron-level accuracy, it gives higher precision than a normal micromanipulator. Since the spindle does not rotate as it advances, instruments can be directly attached without the need for a complicated decoupling device. The digital display eliminates the need to squint at the notational scale. Readings can be clearly seen in either inches or millimeters. You can read both absolute position and the increment relative to a previously chosen point. In addition, there is a digital output port. With optional cable and software SPG-KIT-MICRONR, you can send measurements to your computer either continuously or every time a button on the micrometer is pushed.      Code  502102

 

 

 

 

 

 

 

 

2Biological Instruments

via   L. Da Vinci 2C    -     21023 Besozzo VA      Italy

tel. +39 0332  773210         Fax +39 0332  970141

2biol@2biol.com    www.2biol.com