BP-2000 Blood Pressure Analysis System™ for Mice and Rats

Thank you for your interest in the BP-2000 Blood Pressure Analysis System™.  The BP-2000 is the computerized, non-invasive tail-cuff system that has revolutionized the process of measuring mouse and rat blood pressure.  In use in more than 100 research laboratories worldwide, it is the de facto standard in transgenic and knockout mouse research. 

The BP-2000 has been shown in peer-reviewed scientific research to give results that correlate closely with interarterial measurements (Krege JH, Hodgin JB, Hagaman JR, Smithies O, Hypertension. 1995; 25: 1111-1115).

The BP-2000 can rapidly make multiple measurements simultaneously on up to four animals, without operator intervention. With the BP-2000, you can efficiently and accurately measure blood pressure on large animal populations, for high-throughput phenotyping. 

The BP-2000 is capable of making measuring on one, two, or four animals simultaneously, depending on the model.  The BP-2000 can be expanded as your research needs grow. For example, if you purchase a single-channel system, you can later expand it to a two- or four-channel system by simply upgrading your specimen platform. Similarly, you can start out with a mouse system, and later add rat capability, by getting an additional specimen platform - at a fraction of the cost of a new system.

The BP-2000 offers unprecedented ease in managing your blood pressure data.  The built-in database instantly stores the results of every measurement.  The powerful Report Wizard™ allows you to quickly create customized data reports that contain just the data you want to see, in the way you want to see it.  The data can be exported directly to Microsoft Excel®, or imported into statistics programs for further analysis.

A large and ever-growing number of research papers have been published based on data obtained with the BP-2000 Blood Pressure Analysis System™.  With the BP-2000, you can rest assured that you are working with proven and accepted technology.

 

BP-2000 Features

·         The de facto standard for non-invasive blood pressure analyzers in transgenic and knockout mouse research.

·         Used worldwide in more than 100 laboratories.

·         Cited in more than 80 peer-reviewed research publications.

·         Specifically validated in peer-reviewed scientific research (Krege JH, Hodgin JB, Hagaman JR, Smithies O, Hypertension. 1995; 25: 1111-1115).

·         Shown to give results that correlate closely with interarterial measurements.

·         Measures systolic, diastolic, and mean blood pressure, and heart rate.

·         Capable of making measuring on one, two, or four animals simultaneously, depending on model. 

·         Easily upgrade to additional channels (maximum of four), or add ability to measure both rats and mice, by purchasing a new Specimen Platform - at a fraction of the cost of a whole system.

·         Intuitive, powerful analysis software displays, measures, and stores blood pressure, heart rate, and waveforms.

·         Powerful Report Wizard™ lets you create reports with just the data you want, in the way you want to see it.

·         Automatic temperature control.

·         Precision-engineered cuff elastic gives excellent channel-to-channel consistency.

·         Exports data directly to Excel®

·         Includes a notebook computer and BP-2000 analysis software.

We hope that you will find the BP-2000 Blood Pressure Analysis System to be a valuable and effective tool in your research. If you have any further questions, please do not hesitate to contact us.

"I'm very impressed; it works beautifully and we're able to get tremendous amounts of data in a very short period of time…. I congratulate you and your workers on designing such a fine instrument…."

Professor Jeffrey Robbins,
Children's Hospital Medical Center,
Division of Molecular Cardiovascular Biology,
Cincinnati, OH

 

 

BP-2000 Product Catalog

Complete Mouse Systems

Item

Description

BP-2000-M-1  

BP-2000 Blood Pressure Analysis System, with Single-Channel Mouse Platform, Control Unit, Notebook Computer, Analysis Software License, Accessories Kit, and one Mouse Holder (specify size)

BP-2000-M-2

BP-2000 Blood Pressure Analysis System, with Two-Channel Mouse Platform, Control Unit, Notebook Computer, Analysis Software License, Accessories Kit, and one set of Mouse Holders (specify size)

BP-2000-M-4

BP-2000 Blood Pressure Analysis System, with Four-Channel Mouse Platform, Control Unit, Notebook Computer, Analysis Software License, Accessories Kit, and one set of Mouse Holders (specify size)

 

Complete Rat Systems

BP-2000-R-1  

BP-2000 Blood Pressure Analysis System, with Single-Channel Rat Platform, Control Unit, Notebook Computer, Analysis Software License, Accessories Kit, and one Rat Holder (specify size)  

BP-2000-R-2  

BP-2000 Blood Pressure Analysis System, with Two-Channel Rat Platform, Control Unit, Notebook Computer, Analysis Software License, Accessories Kit, and one set of Rat Holders (specify size)

BP-2000-R-4  

BP-2000 Blood Pressure Analysis System, with Four-Channel Rat Platform, Control Unit, Notebook Computer, Analysis Software License, Accessories Kit, and one set of Rat Holders (specify size)

 

Combined Mouse and Rat Systems

BP-2000-MR-1  

BP-2000 Blood Pressure Analysis System, with
Single-Channel
Mouse Platform, Single-Channel Rat Platform, Control Unit, Notebook Computer, Analysis Software License, Accessories Kit, one Mouse Holder and one Rat Holder (specify size)  

BP-2000-MR-2  

BP-2000 Blood Pressure Analysis System, with
Two-Channel
Mouse Platform, Two-Channel Rat Platform, Control Unit, Notebook Computer, Analysis Software License, Accessories Kit, one set of Mouse Holders, and one set of Rat Holders (specify size)

BP-2000-MR-4  

BP-2000 Blood Pressure Analysis System, with
Four-Channel
Mouse Platform, Four-Channel Rat Platform, Control Unit, Notebook Computer, Analysis Software License, Accessories Kit, one set of Mouse Holders, and one set of Rat Holders (specify size) 

 

Mouse and Rat Holders

BP-MH0

Mouse Holder, Size 0 - for very small mice

BP-MH1  

Mouse Holder, Size 1 - for animals under 30 grams

BP-MH2

Mouse Holder, Size 2 - for animals 30-45 grams

BP-MH3  

Mouse Holder, Size 3 - for animals larger than 45 gm

BP-RH1  

Rat Holder, Size 1 - for animals under 250 grams   

BP-RH2

Rat Holder, Size 2 - for animals 250-400 grams

BP-RH3

Rat Holder, Size 3 - for animals 400-550 grams

 

 

NI BP Recorder family by Panlab

Working range: 0 - 300 mm Hg.

- A silent built-in air pump ensures automated cuff inflation/deflation at a very constant rate.

- Easy to use: press only one button to start the measurement process

- A digital display shows the Systolic, Diastolic and Mean blood pressure & the Heart rate. The digital display also shows the level of the pulse signal.

- All units can be used indistinctly for rats, mice, dogs, using specific pulse transduc. & cuff

- Analog outputs allow for the recording of the cuff pressure and pulse signals.

- Total reliability to realise consecutive measurements on the same animal

- Possibility of monitoring the pressure curve and the heart rate in a PC

 

Option 05PL

All the models can be supplied with the Option 05PL to monitorize and analyse directly pressure and heart rate in the PC.

 

 

 

Model

Data Memory

RS 232

Connection to Heater/Scanner

Programmable

Statistics

LE 5001

No

No

Yes(Manual Switch)

No

No

LE 5002

Up to 6.000

Yes

Yes(Manual Switch)

No

No

LE 5007

Up to 6.000

Yes

Yes(Automatic Switch)

Yes

Yes

 

Heater for Single Holder LE 5610

Provides a comfortable and heated environment, necessary to produce peripheral vasodilation and isolate the animal from external noise

Heater / Scanner

In addition to provide an adequate environment for NIBP measurement, allows to measure it with all the NIBP Systems in several animals:

• Manually switching (up to 6 animals) in models LE 5640/6 (Rats) and LE 5655/6 (Mice)
• Automatically (up to 12 animals, only LE 5007) in models LE 5650/6 (Rats) and LE 5660/6 (Mice)

 

 

 

Infrared Lamp

Very useful to pre-warm animals before carrying out Non Invasive Blood Pressure measurements on their tail.  This save times, ensures more reliable results and enables the operator to measure quickly large numbers of  animals.

The lamp can also be used to warm animals after surgery and it can be driven by a rectal probe and thermostatic electronic unit . Power is 250 W.

Code LIR 250W  Infrared Lamp

Code HB 121  Electronic unit with rectal probe (specify mouse or rat)

 

 

INVASIVE MEASUREMENTS

 

LOW COST Blood Pressure Transducer  BLPR2

 

BLPR can be used for the direct arterial and venous pressure measurement in animal blood vessels.

 

Range –30 +300 mmHg.

Sensitivity  50uV/V/cmHg

 

Code BLPR2  Blood Pressure Transducers

Code STK  Pkg of 10 3 way stopcock

 

 

BLOOD PRESSURE MONITOR 

Analog single-channel transducer signal conditioner

 

An analog signal conditioner for monitoring pressure, force, temperature, and other physical parameters provided by transducers, BP-1 Pressure Monitor is designed to monitor animal arterial or venous blood pressure, displaying systolic, diastolic or average blood pressure. BP-1 accepts any blood pressure transducer as well as other transducers (force, temperature, etc).

An audio monitor provides a signal with variable pitch and amplitude, allowing you to hear changes in blood pressure. Digital LCD display provides average or peak signal values from 0 to 1999 mV.

When supplied with an optional pressure gauge, the LCD shows pressure in mm Hg. Recorder output connector allows direct connection to a pen recorder, oscilloscope or computer front end.

Code BP-1  Blood Pressure Monitor

 

Make your own catheters by our PE & Silastic Tubing coils, click here: PE & Silastic Tubing

Special catheters Home Made Luer-Lock Fitting available on request

 

A wide range of any Kind of Catheters available here: WIDE RANGE OF CATHETERS

 

DATA ACQUISITION SYSTEM FOR BLPR RECORD. & ANALYSES, click here:  MP Biopac DAC

 

 

 

LATEX BALLOONS

The balloon catheter 170423 (for sizes 3-4)and 170424 (for sizes 5-6) are for ventricular insertion. It is a simple, reliable way to measure left ventricular isovolumetric pressure.

Species

Body Weight Kg.

Balloon Size

Volume (ml)

Sizes Dia.xLength mm

 

Code

Rat

0.1-0.2

3

0.03

3x7

170403

Guinea-Pig

0.3-0.4

4

0.06

4x8

170404

Pig

0.5

5

0.1

5x9

170405

Rabbit(sml)

0.7

6

0.2

6x10

170406

 

Pressure Calibrators

 

Friendly, easy to use Mercury or analog PRESSURE CALIBRATOR.

Very useful to calibrate and check Range in Blood Pressure Transducers and in the Non Invasive BP Recorder apparatus.  Range 0-200 mmHg.

 

Code HGCAL  Mercury Pressure manometer  (picture at right)

                           Available in 3 colors: Blue, Red, Green

 

Code ANHGCAL  Analog Pressure Calibrator  (picture at left)

 

Veterinary Patient MONITOR -  Code 33721

ECG + SpO2 + NIBP + BREATHING + TEMPERATURE


HEART RATE -  range: 15-300 bpm ±2bpm
ECG - Lead selection: I, II, III, V, aVR, aVL, aVF
NIBP - Method automatic oscillometric - Parameters: systolic, diastolic, mean
Cuff pressure: big animals 0 - 300 mmHg - little animals 0 - 150 mmHg
SpO2 - Measure range: 0 - 100%
TEMPERATURE - Measurement and alarm range: 0 - 50 °C
RESPIRATION - Measurement method: thoracic impedance
Respiration rate range: 0 - 150 brpm ±2 brpm

7" inch color TFT display
4-channel waveform display
2-channel ECG real-time display
600-set blood pressure data storage
48-hour trend

RECORDER (OPTIONAL) - External thermal printer

 

CARDIO-3M - 3 cannel ECG with monitor

 

- LCD display, 1 or 3 channels in Standard or Cabrera format with base line setting. - High resolution thermal printer (8 dots/mm): hardcopy 1 or 3 channels real time with possibility to print the millimetric grid. - Recording manual or automatic - Memory 10 seconds for each lead - Image freeze with memory scrolling for reviewing and hard copy of acquired signals - Digital filters for elimination of muscle tremors, power line and base line disturbs
- Power supply by internal Ni- Cd batteries with high capacity and fast charge time - Operation very simple through pre- defined fast keys and menus - Portable with small dimensions and light weight
- Based on a risc processor for a full digital signal processing.

 

 

 

PORTABLE ECOGRAPH

 

-  10” SVGA monitor with one probe connector, without probes.
-  Zooming and measurement functions
-  Wide applications: GYN, urology, abdominal, small parts
-  Easy to use, just one day to learn all functions
-  4- steps sweep speeds for cardiac study: 2s, 4s, 6s, 8s
-  4- steps zoom with depth control: x0.8, x1.0, x1.5, x2.0
-  Various measurements: Distance, Circumference, Area, Volume
-  Full Ob/Gyn software included: 7 EDD tables (BPD, GS, FL, AD, HC, AC, CRL), G.A. (fetal age) from 4- 43 weeks
-  Fetal weight, fetal heart rate measurement
-  Imaging reversing: up/down, left/right, positive/negative
-  Power supply: 230 V/50 Hz (110V/60 Hz on request)

 

Code 33332 Portable Ecograph

A wide range of probes available

 

 

Automated

Blood Sampler

 

Instech's ABS2™ automates the collection of blood samples from laboratory animals. By eliminating labor-intensive manual withdrawals it can streamline DMPK research. It can also reduce the stress on animals caused by handling. The sampler withdraws blood from a tethered freely-moving animal according to your programmed schedule, stores the samples in an integrated refrigerated fraction collector, and replaces the withdrawn volumes with IV fluid. You control and monitor sampling schedules, volumes and withdrawal rates for up to twelve animals from a central computer. Unique advantages of the Instech blood sampling system include:   

Undiluted samples, verified by in-line sensors A short collection path, to minimize mixing and collection times  Less than 5 µL of blood wasted per sample, to minimize hemodilution. 

 

 

 The flexibility to work with a range of species, from mice and rats to large animals.  The ABS2, Instech's second-generation autosampler, builds on the proven foundation of a series of precision peristaltic pumps to move blood and IV fluids directly to their destinations. The fraction collector has been redesigned from the ground up for additional features and high reliability.

The ABS2 not only works with refrigerated vials, but also can deposit 10-25µL samples directly onto dried blood spot paper. The dried blood spot technique offers several advantages over traditional sampling, including very small sample volumes, streamlined processing and room temperature storage.

 

Code  ABS2

 

Pulse Oximeter for Mice and Rats

 

Non-invasive sensor for surgery monitoring

Features

  • Use as a cardiopulmonary data recorder
  • Quickly check vital signs
  • Record real-time changes in: arterial oxygen saturation, pulse rate, breath rate, pulse distention, breath distention, output analog data, and record oxygen saturation
  • Use as a surgery monitor
  • Prevent hypoxia during surgery
  • Titrate mechanical ventilation
  • Monitor depth of anesthesia
  • Titrate supplemental oxygen
  • Accurate measurements up to         900 bpm

 

The Mouse/Rat Oximeter system provides real-time, continouous measurements of arterial O2 saturation, pulse rate, breath rate, blood flow, and effort to breath. All from a single, non-invasive sensor. Because this unique system was developed specifically for mice and rats, it provides accurate measurements for heart rates up to 900bpm.

  • Multiple cardiopulmonary measurements from one non-invasive sensor clip
  • Immediate responding, beat-by-beat measurements
  • High accuracy at heart rates up to 900 BPM and breath rates up to 600 BrPM
  • Drawing of blood is not required for any reason
  • Simple non-invasive sensor clip enables quick and easy attachment to the subject
  • USB plug-and-play technology quickly and easily turns your Window’s™ -based computer into a low-cost physiologic monitor
  • Monitor data in real-time, while recording to a file at 15 Hz
  • Experiment event markers allow the user to mark important events in the data file
  • Small, lightweight, USB-based Oximeter unit is easily moved from computer to computer. Fits into a lab coat pocket. 

 

55500V

MouseOx System

55511

CollarClip, >500g, Rat, awake

55501V

MouseOx System w/Analog Output

55512

ThroatClip, 1-20g, Mouse, anesthetized

55502V

MouseOx System, MRI

55513

ThroatClip, >20g Mouse or 5-30g Rat, anesthetized

55503V

MouseOx System w/Analog Output, MRI

55514

ThroatClip, 31-100g, Rat, anesthetized

55506

CollarClip, 1-20g, Mouse, awake

55515

ThroatClip, 101-300g, Rat, anesthetized

55507

CollarClip, >20g Mouse or 5-30g Rat, awake

55516

ThroatClip, 301-500g, Rat, anesthetized

55508

CollarClip, 31-100g, Rat, awake

55517

ThroatClip, >500g, Rat, anesthetized

55509

CollarClip, 101-300g, Rat, awake

55518

Thigh Sensor (standard), Mice/Rats, anesthetized

55510

CollarClip, 301-500g, Rat, awake

55519

Foot Sensor, Rat, anesthetized

 

Restrainers and Tailveiner

 

 

 

 

The TAILVEINER® is the first easy to use mouse and rat restrainer specifically designed for tail vein injections. The slotted tube permits the rat or mouse to be quickly pulled in by the tail. The animal is then restrained by a tapered plug which slides easily to accommodate any size rat or mouse, but locks automatically when handle is released. The tailveiner® is the fastest restrainer yet for intravenous injections in small animals.

Code TV 150  Tailveiner for Mice

Code RTV 170 Tailveiner for Rats up to 120 grams

Code RTV 180 Tailveiner for Rats up to 350 grams

Code RTV 190 Tailveiner for Rats up to 500 grams

 

Restrainers:

The most common used Rodent Restrainers especially suitable for BP measurement. Conditioning of the animal is advisable before starting real treatment.

 

Code LE 5016 Restrainers for Mice up to 35 grams

Code LE 5018 Restrainers for Mice up to 50 grams

Code LE 5020 Restrainers for Rats up to 150 grams

Code LE 5024 Restrainers for Rats up to 400 grams

Code LE 5025 Restrainers for Rats up to 500 grams

 

Restrainer for bigger animals (Rabbits) available

 

Pie Cages

 

Circular cages hold up to 10 mice or 11 rats. The notched removable lid can be dialed to any of the ventilated pie- shaped chambers. These units were originally designed for whole body irradiation. Use for temporary transport or storage of animals for acute studies. The rat cage has tail slots for intravenous dosing.

 

Code MPC  Mouse Pie Cage

Code RPC-1 Small Rat Pie Cage (up to 250 grams)

Code RPC-2 larger Rat Pie Cage (up to 400 grams)

 

2Biological Instruments

via   L. Da Vinci 2C    -     21023 Besozzo VA      Italy

tel. +39 0332  773210         Fax +39 0332 970141

2biol@2biol.com      www.2biol.com