3100 Incapacitance Tester

an unique device for analgesic and anti-inflammatory test


Dual Weight Averager

(Incapacitance Tester)


A new instrument which offers an automatic and reproducible  assessment of analgesic potency by measuring the weight distribution on the two hind paws of a small animal. The force exerted by each limb (measured in grams) is averaged over a user selectable period thus indicating any tendency for the animal to shift its weight from one side to another, hence providing a quantitative measurement of Incapacitance. The technique of the Dual Weight Averager overcomes a number of deficiences inherent in the traditional method of pain/inflammation assessment by presenting continuous monitoring of both limbs and by eliminating the subjectivity of other instruments.



3100  Incapacitance Test For Rats

3200 Incapacitance Tester for Mice

3300 Incapacitance Tester Rabbits





-  Neuroscience  Vol. 78   No. 3  pp. 843-850  1997 

-  Journal of Neuroscience Methods 81 (1998) pp.  139-141

-  JPM  Vol. 31  No. 2 April  1994: 79-83 

-  OsteoArthitis and Cartilage (2003)  11     821-830

-  PAIN  Vol. 114 – 2005   (386-396) NEW on MOUSE



HOT / COLD Plate

Hot/Cold Plate Analgesia Meter is based on a metal plate which can be heated to 65°C and cooled to -3°C.  The animal pain sensitivity resulting from exposure to heat or cold is tested by placing the animal on the surface of the plate and starting a built-in timer. The operator stops the timer at the instant the animal lifts its paw from the plate, reacting to the discomfort. The front panel timer then displays the number of seconds the animal took to react. Animal reaction time is a measurement of animal resistance to pain and is used to measure efficacy of analgesics. The plate is designed to be very simple to use at very fast to reach the set temperature (From ambient to 4°C, the most used threhold value, it takes less than 10 minutes, and from 4°C to 65°C it takes only 5 minutes) . Metrology wise, is accurate to less than 0,5°C (EEC metrology standard) and perfectly constant in the animal holder system. The preset temperature will not change for more than 0,1°C when a 400g rat is placed on the plate, and return to the set temperature is almost immediate.  In addition, the instrument can be adjusted to be used for "TEMPERATURE RAMPS" , predefined by the user,

Code LE7420  HOT COLD Plate




Hot Plate

The Hot Plate enables the assessment of the activity of analgesic drugs according to the "Hot Plate Test". This method evaluates the reaction time of mice which are dropped on a heated surface and thus confronted with a heat stimulus applied to the plantar surface.    The plate temperature can be controlled between 45º C and 62º C, in 0.1º C steps. A built-in timer (0.01 sec steps) activated by an external pedal allows for the precise measurement of the reaction time.

A RS 232 port and a data-communication software allows for the transfer of data to a computer. A Perspex cylinder is also included in the standard package.

LE 7406  Hot Plate  complete of software for PC


Tail Flick

Analgesy-meter based on the measurement of the latency of the avoidance response elicited in an experiment when pain is induced by radiant heat applied to the animal's tail. According to the D'Amour & Smith test, when the animal reacts against pain by a sudden tail movement (tail flick), the stimulation stops and the reaction time is measured by a digital clock. By its RS 232 output it is able export the response time directly to the Computer for statistical analysis.

LE 7106  Tail Flick complete of software for PC



336 Plantar Test (Hargreaves)

The 336 Plantar Test and Tail Flick Test Analgesia Meter is used to test the properties of narcotic and stronger non-narcotic drugs on unrestrained mice and rats. The test is made on the plantar surface of rodents by a focused, radiant heat light source which emits from the test head. The test head is placed under a tempered glass surface and slides on

top of the supplied base with Teflon balls to the desired position. The light beam is focused to the top of the glass and creates a 4X6mm intense spot on the paw. Prior to testing there is a “guide” light to assist in directing the beam to the precise spot. An adjustable angled mirror is mounted on top of the test head to help the operator to view the paw without constant bending. The use of visible light compares favorably with an infrared light source since the user does not always know exactly where the test will start, this causes false starts and conditioning of animals which occurs with other versions of this type of test on the market.         Code 336  Plantar Test  (Hargreaves Method)

OPTIONAL:  Code TG  -  Heated Glass to ensure constant environmental measurement conditions



Analgesy-Meter  Randall Selitto

The LE 7306 is  since 1965, a very well known device in a number of academic and industrial laboratories, is helping to perform a rapid precise screening of analgesic drugs, according to Randall-Selitto Test. The LE 7306  is one of the most popular instruments in the World with thousands of bibliography papers already worked out


Code LE 7306  Paw Analgesy Meter + Software


Electronic Von Frey


The electronic model EVF2 combines ease of use and rapidity of the determination of the pain threshold. The value is detected in a single measurement and can be reproduced. The same equipment can be used to work on the animal and also in the clinic, with a resolution of 0,1gf.

Code EVF2  Electronic Von Frey Unit




Electronic von Frey Anesthesiometer

Our electronic unit now has the capability of testing not only the Electronic von Frey method but also Plethysmometer (Paw Volume) and perform the Randall Selitto Test; all test results digitally recorded with one simple easy to use unit. The Electronic Von Frey Aesthesiometer has been introduced over 7 years ago, now the standard for pain and sensory measurements. A patented solution to paw pressure threshold measurements. Simple to use: All that is required is to apply pressure to the subject and upon reaction the system will automatically record and display the force applied (force shown in grams). The system will display current reading, maximum hold reading. Tips are reusable and additional can be ordered as well. A clean efficient system for anyone looking to measure allodynia on any test subject today.




The Digital Water Plethysmometer is an instrument designed to provide a useful tool in the measurement of small volume changes. The volume transducer is formed by two Perspex tubes, which are interconnected and filled with a conductive solution.  The water displacement produced by the immersion of an object in the measuring tube induces a change in the conductance, as measured between two platinum electrodes in the second tube. The electronic circuit provides great measuring stability and the device has an RS 232 output.

LE 7500 Plethysmometer unit complete of software



This principle makes it possible for the researcher using a hand held probe to apply a reproducible force, within a wide tolerance, to the skin surface.  Rodents exhibit a paw withdrawal reflex when the paw is unexpectedly touched. The Touch Test™ Sensory Evaluator can be used on the Plantar surfaces of the foot of a rat or mouse, and the animal will indicate sensation by pulling back its paw. Replacement filaments available.


Code 58011  Von Frey Filaments


Touch Test Sensory Evaluator Kit

Von Frey Filaments - Aesthesiometer

Semmes Weinstein Von Frey Aesthesiometer for Touch Assessment

This set of 20 monofilaments is based on the Semmes Weinstein monofilament set, but now features retractable filaments to protect the filament and allow the investigator to carry a few around in a pocket.  The Semmes Weinstein set of monofilaments provide an approximately logarithmic scale of actual force, and a linear scale of perceived intensity. They have a long history of effective use in clinical settings, and can be used to diagnose pathologies of hyper- or hypo-aesthesia. Subsets within the set of 20 probes distinguish pathologies on different parts of the body (foot, hand, lip, cheek, etc.). The operating principle remains the same: when the tip of a fiber of given length and diameter is pressed against the skin at right angles, the force of application increases as long as the researcher continues to advance the probe, until the fiber bends. After the fiber bends, continued advance creates more bend, but not more force of application.


Mesh Stands for the Electronic or Manual Von Frey

The latest version on the Model 2390 series enables the user to plug up to 3 probes into a single unit. Multiple users have the ability to use one single unit for multiple studies. The mesh stands are now available with 16" legs for ease of viewing when doing the von Frey test.

410 Mesh Stand for Multiple Animal

Testing (6 rats 12 Mice)

406 Mesh Stand (small) for Multiple Animal

Testing (2 Rats 4 Mice)


Grip Strength Meter

Grip Strength Meters are employed in assessing neuromuscular function by sensing the peak amount of force an animal applies in grasping specially designed pull bar assemblies. Metering is performed with precision force gauges in such a manner as to retain the peak force applied on a digital display. The values may be either recorded manually or automatically via serial port  RS-232 interface available on the computerized model(s).  Grid (metal network) or Grip (Trapeze shape) tools for mice and rats available.


Code BS-GRP  Grip Strength Meter for rats and mice /with one grip or bar)

Code BS-GRR Additional Grip for Rats  (or mice code BS-GRM)

Code BS-GBR Additional Bar for Rats  (or mice code BS-GBM)



Rodent Pincher

The New Rodent Pincher allows researchers to measure and test pain threshold in a simple, accurate method when measuring pain nociception.  The system can be used on mice or rats and will measure and display in grams the amount of force that has been applied to the animals paw. Accuracy is .01 grams, no calibration needed.


Code 2450 Rodent Pincher System Analgesia Meter

Code 2455 Rodent Pincher - Pincher only




2Biological Instruments

via   L. Da Vinci 2C    -     21023 Besozzo VA      Italy

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