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Hot/Cold
Plate Analgesia Meter is based on a metal plate which can be heated to 65°C
and cooled to -3°C. The animal pain
sensitivity resulting from exposure to heat or cold is tested by placing the
animal on the surface of the plate and starting a built-in timer. The
operator stops the timer at the instant the animal lifts its paw from the
plate, reacting to the discomfort. The front panel timer then displays the
number of seconds the animal took to react. Animal reaction time is a
measurement of animal resistance to pain and is used to measure efficacy of
analgesics. The plate is designed to be very simple to use at very fast to
reach the set temperature (From ambient to 4°C, the most used threhold value,
it takes less than 10 minutes, and from 4°C to 65°C it takes only 5 minutes)
. Metrology wise, is accurate to less than 0,5°C (EEC metrology standard) and
perfectly constant in the animal holder system. The preset temperature will
not change for more than 0,1°C when a 400g rat is placed on the plate, and
return to the set temperature is almost immediate. In addition, the instrument can be adjusted to be used for
"TEMPERATURE RAMPS" , predefined by the user, Code
LE7420 HOT COLD Plate
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The Hot Plate enables the assessment
of the activity of analgesic drugs according to the "Hot Plate
Test". This method evaluates the reaction time of mice which are dropped
on a heated surface and thus confronted with a heat stimulus applied to the
plantar surface. The plate temperature
can be controlled between 45º C and 62º C, in 0.1º C steps. A built-in timer
(0.01 sec steps) activated by an external pedal allows for the precise
measurement of the reaction time. A RS 232 port and a
data-communication software allows for the transfer of data to a computer. A
Perspex cylinder is also included in the standard package. LE 7406
Hot Plate complete of software
for PC |
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Analgesy-meter based on
the measurement of the latency of the avoidance response elicited in an experiment
when pain is induced by radiant heat applied to the animal's tail. According
to the D'Amour & Smith test, when the animal reacts against pain by a
sudden tail movement (tail flick), the stimulation stops and the reaction
time is measured by a digital clock. By its RS 232 output it is able export
the response time directly to the Computer for statistical analysis. LE 7106
Tail Flick complete of software for PC |
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336 Plantar Test (Hargreaves) The 336 Plantar Test and Tail Flick Test Analgesia Meter is used to
test the properties of narcotic and stronger non-narcotic drugs on
unrestrained mice and rats. The test is made on the plantar surface of
rodents by a focused, radiant heat light source which emits from the test
head. The test head is placed under a tempered glass surface and slides on |
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top
of the supplied base with Teflon balls to the desired
position. The light beam is focused to the top of the glass and creates a
4X6mm intense spot on the paw. Prior to testing there is a “guide” light to
assist in directing the beam to the precise spot. An adjustable angled mirror
is mounted on top of the test head to help the operator to view the paw
without constant bending. The use of visible light compares favorably with an
infrared light source since the user does not always know exactly where the
test will start, this causes false starts and conditioning of animals which
occurs with other versions of this type of test on the market. Code 336 Plantar Test (Hargreaves Method) OPTIONAL: Code TG - Heated Glass to ensure constant environmental measurement conditions |
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Analgesy-Meter Randall Selitto The
LE 7306 is since 1965, a very well known
device in a number of academic and industrial laboratories, is helping to
perform a rapid precise screening of analgesic drugs, according to
Randall-Selitto Test. The LE 7306 is
one of the most popular instruments in the World with thousands of bibliography
papers already worked out Code LE 7306 Paw Analgesy Meter + Software |
Electronic Von Frey
Aesthesiometer
The electronic model EVF2 combines ease of use and
rapidity of the determination of the pain threshold. The value is detected in
a single measurement and can be reproduced. The same equipment can be used to
work on the animal and also in the clinic, with a resolution of 0,1gf. Code EVF2 Electronic Von
Frey Unit |
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Electronic von Frey Anesthesiometer
Our electronic unit now has
the capability of testing not only the Electronic von Frey method but also
Plethysmometer (Paw Volume) and perform the Randall Selitto Test; all test
results digitally recorded with one simple easy to use unit. The Electronic Von
Frey Aesthesiometer has been introduced over 7 years ago, now the standard
for pain and sensory measurements. A patented solution to paw pressure
threshold measurements. Simple to use: All that is required is to apply
pressure to the subject and upon reaction the system will automatically
record and display the force applied (force shown in grams). The system will
display current reading, maximum hold reading. Tips are reusable and
additional can be ordered as well. A clean efficient system for anyone looking
to measure allodynia on any test subject today. |
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The Digital Water
Plethysmometer is an instrument designed to provide a useful tool in the
measurement of small volume changes. The volume transducer is formed by two
Perspex tubes, which are interconnected and filled with a conductive
solution. The water displacement
produced by the immersion of an object in the measuring tube induces a change
in the conductance, as measured between two platinum electrodes in the second
tube. The electronic circuit provides great measuring stability and the
device has an RS 232 output. LE 7500 Plethysmometer unit complete of
software |
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This principle makes it possible for the researcher using a hand held probe
to apply a reproducible force, within a wide tolerance, to the skin surface. Rodents exhibit a paw withdrawal reflex when the paw is unexpectedly
touched. The Touch Test™ Sensory Evaluator can be used on the Plantar
surfaces of the foot of a rat or mouse, and the animal will indicate
sensation by pulling back its paw. Replacement filaments
available. Code
58011 Von Frey Filaments |
Touch Test Sensory Evaluator Kit Von Frey Filaments - Aesthesiometer
Semmes
Weinstein Von Frey Aesthesiometer for Touch Assessment This set of 20 monofilaments is based on the
Semmes Weinstein monofilament set, but now features retractable filaments
to protect the filament and allow the investigator to carry a few around in a
pocket. The Semmes Weinstein set of
monofilaments provide an approximately logarithmic scale of actual force, and
a linear scale of perceived intensity. They have a long history of effective
use in clinical settings, and can be used to diagnose pathologies of hyper-
or hypo-aesthesia. Subsets within the set of 20 probes distinguish
pathologies on different parts of the body (foot, hand, lip, cheek, etc.).
The operating principle remains the same: when the tip of a fiber of given
length and diameter is pressed against the skin at right angles, the force of
application increases as long as the researcher continues to advance the
probe, until the fiber bends. After the fiber bends, continued advance
creates more bend, but not more force of application. |
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Mesh Stands for the Electronic or Manual Von Frey The
latest version on the Model 2390 series enables the user to plug up to 3
probes into a single unit. Multiple users have the ability to use one single unit
for multiple studies. The mesh stands are now available with 16" legs
for ease of viewing when doing the von Frey test. 410 Mesh Stand for Multiple Animal Testing (6 rats 12 Mice) 406 Mesh Stand (small) for Multiple Animal Testing (2 Rats 4 Mice) |
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Grip
Strength Meter
Grip
Strength Meters are employed in assessing neuromuscular function by sensing
the peak amount of force an animal applies in grasping specially designed
pull bar assemblies. Metering is performed with precision force gauges in
such a manner as to retain the peak force applied on a digital display. The
values may be either recorded manually or automatically via serial port RS-232 interface available on the
computerized model(s). Grid (metal
network) or Grip (Trapeze shape) tools for mice and rats available. Code BS-GRP Grip Strength Meter for rats and mice /with
one grip or bar) Code BS-GRR
Additional Grip for Rats (or mice code
BS-GRM) Code BS-GBR
Additional Bar for Rats (or mice code
BS-GBM) |
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The
New Rodent Pincher allows researchers to measure and test pain threshold in a
simple, accurate method when measuring pain nociception. The system can be used on mice or rats and
will measure and display in grams the amount of force that has been applied
to the animals paw. Accuracy is .01 grams, no calibration needed. Code 2450 Rodent
Pincher System Analgesia Meter Code 2455 Rodent
Pincher - Pincher only |
2Biological Instruments
via L. Da Vinci 2C - 21023 Besozzo
VA Italy
tel. +39 0332 773210 Fax +39 0332 970141